Linked Life Data

8533321

Source:http://linkedlifedata.com/resource/pubmed/id/8533321

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
1996-1-29
pubmed:abstractText
To study human cone phototransduction, the alpha-wave of the ERG was recorded from color normals, dichromats, and patients with retinitis pigmentosa. A model of the activation phase of phototransduction, previously fitted to responses from single rods and the rod alpha-wave, was modified and fitted to the human cone alpha-wave. The modified model fits the cone alpha-wave well and allows questions about human cone phototransduction to be addressed. In particular, we conclude that: (1) the amplification of the activation phase of human cone transduction is comparable to that of the human rods. (2) Steady lights have relatively little effect on the amplification of cone transduction. (3) The normal alpha-wave elicited by red flashes is dominated by the L cones, consistent with a ratio of L:M cones of > 1. (4) Retinitis pigmentosa caused by mutations of the rhodopsin gene can affect cone phototransduction. Finally, a simpler computational expression is shown to approximate the modified model's responses.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0042-6989
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2801-10
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Phototransduction in human cones measured using the alpha-wave of the ERG.
pubmed:affiliation
Department of Psychology, Columbia University, New York, NY 10027, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't