rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1-2
|
pubmed:dateCreated |
1996-1-31
|
pubmed:abstractText |
This report describes the immunocytochemical detection and distribution of different canine leucocytes antigens (Thy-1, CD5, CD4, CD8, MHC-II and B-cell antigen) by means of monoclonal antibodies (mAbs) in frozen tissue sections of lymphoid organs of the dog. CD5 is expressed exclusively by T lymphocytes. Thy-1 is expressed by T-lymphocytes and in a variety of non-lymphoid tissues. The mAb against canine MHC-II could detect B and T lymphocytes, macrophages, fibroblasts and antigen presenting cells. The CD4 antigen is expressed on many lymphocytes of the T-dependent areas of lymph organs and is also expressed by certain antigen presenting cells. CD8 is expressed in a minor proportion of T cells. The mAb against B cells detected lymphocytes in lymphoid follicles and epithelial cells of the thymic medulla.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0165-2427
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
47
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
13-23
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8533290-Animals,
pubmed-meshheading:8533290-Antibodies, Monoclonal,
pubmed-meshheading:8533290-Antigen-Presenting Cells,
pubmed-meshheading:8533290-Antigens, CD,
pubmed-meshheading:8533290-Antigens, Thy-1,
pubmed-meshheading:8533290-B-Lymphocytes,
pubmed-meshheading:8533290-Dogs,
pubmed-meshheading:8533290-Histocompatibility Antigens,
pubmed-meshheading:8533290-Histocompatibility Antigens Class II,
pubmed-meshheading:8533290-Immunoenzyme Techniques,
pubmed-meshheading:8533290-Kidney,
pubmed-meshheading:8533290-Liver,
pubmed-meshheading:8533290-Lymphoid Tissue,
pubmed-meshheading:8533290-Skin,
pubmed-meshheading:8533290-T-Lymphocytes
|
pubmed:year |
1995
|
pubmed:articleTitle |
Immunohistochemical detection of canine leucocyte antigens by specific monoclonal antibodies in canine normal tissues.
|
pubmed:affiliation |
Departament de Patologia i Producció Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|