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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5244
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pubmed:dateCreated |
1996-1-30
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pubmed:databankReference |
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pubmed:abstractText |
Hydrolysis of guanosine triphosphate (GTP) by the small guanosine triphosphatase (GTPase) adenosine diphosphate ribosylation factor-1 (ARF1) depends on a GTPase-activating protein (GAP). A complementary DNA encoding the ARF1 GAP was cloned from rat liver and predicts a protein with a zinc finger motif near the amino terminus. The GAP function required an intact zinc finger and additional amino-terminal residues. The ARF1 GAP was localized to the Golgi complex and was redistributed into a cytosolic pattern when cells were treated with brefeldin A, a drug that prevents ARF1-dependent association of coat proteins with the Golgi. Thus, the GAP is likely to be recruited to the Golgi by an ARF1-dependent mechanism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
270
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1999-2002
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:8533093-ADP-Ribosylation Factor 1,
pubmed-meshheading:8533093-ADP-Ribosylation Factors,
pubmed-meshheading:8533093-Alternative Splicing,
pubmed-meshheading:8533093-Amino Acid Sequence,
pubmed-meshheading:8533093-Animals,
pubmed-meshheading:8533093-Base Sequence,
pubmed-meshheading:8533093-Brefeldin A,
pubmed-meshheading:8533093-Cloning, Molecular,
pubmed-meshheading:8533093-Cyclopentanes,
pubmed-meshheading:8533093-Cytosol,
pubmed-meshheading:8533093-DNA, Complementary,
pubmed-meshheading:8533093-GTP-Binding Proteins,
pubmed-meshheading:8533093-GTPase-Activating Proteins,
pubmed-meshheading:8533093-Golgi Apparatus,
pubmed-meshheading:8533093-Guanosine Triphosphate,
pubmed-meshheading:8533093-Liver,
pubmed-meshheading:8533093-Molecular Sequence Data,
pubmed-meshheading:8533093-Proteins,
pubmed-meshheading:8533093-Rats,
pubmed-meshheading:8533093-Zinc Fingers
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pubmed:year |
1995
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pubmed:articleTitle |
The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization.
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pubmed:affiliation |
Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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