rdf:type |
|
lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0021311,
umls-concept:C0021747,
umls-concept:C0026882,
umls-concept:C0030705,
umls-concept:C0033684,
umls-concept:C0220847,
umls-concept:C0524910,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
pubmed:issue |
2
|
pubmed:dateCreated |
1996-1-26
|
pubmed:abstractText |
A region associated with sensitivity to interferon has been identified in the nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) genotype 1b. The region spans amino acid residues 2209 to 2248 (NS5A2209-2248) of HCV-J, a strain of HCV-1b whose complete genomic sequence has been identified. We examined whether the NS5A2209-2248 sequence present before therapy could be used as a predictor of the response to interferon therapy in patients with chronic HCV-1b infection.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0028-4793
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
11
|
pubmed:volume |
334
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
77-81
|
pubmed:dateRevised |
2010-3-24
|
pubmed:meshHeading |
pubmed-meshheading:8531962-Amino Acid Sequence,
pubmed-meshheading:8531962-Base Sequence,
pubmed-meshheading:8531962-Chronic Disease,
pubmed-meshheading:8531962-Female,
pubmed-meshheading:8531962-Hepacivirus,
pubmed-meshheading:8531962-Hepatitis C,
pubmed-meshheading:8531962-Humans,
pubmed-meshheading:8531962-Interferon-alpha,
pubmed-meshheading:8531962-Male,
pubmed-meshheading:8531962-Middle Aged,
pubmed-meshheading:8531962-Molecular Sequence Data,
pubmed-meshheading:8531962-Multivariate Analysis,
pubmed-meshheading:8531962-Mutation,
pubmed-meshheading:8531962-RNA, Viral,
pubmed-meshheading:8531962-Retrospective Studies,
pubmed-meshheading:8531962-Treatment Outcome,
pubmed-meshheading:8531962-Viral Nonstructural Proteins
|
pubmed:year |
1996
|
pubmed:articleTitle |
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.
|
pubmed:affiliation |
Second Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|