Linked Life Data

8531213

Source:http://linkedlifedata.com/resource/pubmed/id/8531213

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1996-2-1
pubmed:abstractText
Phalloidin binds very tightly and specifically to actin and brings about a marked stabilization of the F-actin filament. In this study the effects of phalloidin on force generation and Ca2+ sensitivity of skinned bovine ventricular muscle were investigated. At all free Ca2+ concentrations addition of phalloidin to activated fibers caused an enhancement of active force. At full Ca2+ activation the force increase was about 6% and the relative force enhancement became greater as the Ca2+ concentration was decreased. Force-pCa plots obtained with fibers pre-treated with phalloidin showed that phalloidin produced an approximately 0.2 pCa unit increase in Ca2+ sensitivity without significant changes in cooperativity of activation. These results suggest that interactions between G-actin subunits may play an important role in cardiac force development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-2828
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1311-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Thin filament activation by phalloidin in skinned cardiac muscle.
pubmed:affiliation
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.