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rdf:type |
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lifeskim:mentions |
umls-concept:C0001752,
umls-concept:C0008633,
umls-concept:C0017337,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0035687,
umls-concept:C0086418,
umls-concept:C0475264,
umls-concept:C0679058,
umls-concept:C1419989,
umls-concept:C1419992,
umls-concept:C1521761,
umls-concept:C1547699,
umls-concept:C2700640
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pubmed:issue |
1
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pubmed:dateCreated |
1996-2-1
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pubmed:abstractText |
The mammalian SR-type splicing factors ASF/SF2 and SC-35 play crucial roles in pre-mRNA splicing and have been shown to shift splice site choice in vitro. We have mapped the ASF/SF2 gene in mice and humans and the SC-35 gene in mice. Somatic cell hybrid mapping of the human ASF/SF2 gene (SFRS1 locus) reveals that it resides on chromosome 17, and fluorescence in situ hybridization refines this localization to 17q21.3-q22. Recombinant inbred mapping of the mouse ASF/SF2 gene (Sfrs1 locus) and the mouse SC-35 gene (Sfrs2 locus) demonstrates that both genes are located in a part of mouse chromosome 11 that is homologous to human chromosome 17. Mapping of Sfrs1 using F1 hybrid backcross mice between the strains C57BL/6 and DDK places Sfrs1 very near the marker D11Mit38 and indicates that the ASF/SF2 gene is closely linked to the Ovum mutant locus.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
70-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8530103-Alternative Splicing,
pubmed-meshheading:8530103-Animals,
pubmed-meshheading:8530103-Chromosome Mapping,
pubmed-meshheading:8530103-Chromosomes, Human, Pair 17,
pubmed-meshheading:8530103-Cricetinae,
pubmed-meshheading:8530103-Crosses, Genetic,
pubmed-meshheading:8530103-Female,
pubmed-meshheading:8530103-Hominidae,
pubmed-meshheading:8530103-Humans,
pubmed-meshheading:8530103-Hybrid Cells,
pubmed-meshheading:8530103-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8530103-Male,
pubmed-meshheading:8530103-Mice,
pubmed-meshheading:8530103-Mice, Inbred Strains,
pubmed-meshheading:8530103-Nuclear Proteins,
pubmed-meshheading:8530103-RNA Splicing,
pubmed-meshheading:8530103-RNA-Binding Proteins,
pubmed-meshheading:8530103-Recombination, Genetic,
pubmed-meshheading:8530103-Ribonucleoproteins,
pubmed-meshheading:8530103-Species Specificity
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pubmed:year |
1995
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pubmed:articleTitle |
Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2).
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pubmed:affiliation |
University of California at San Diego, La Jolla 92093-0660, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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