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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-1-26
|
| pubmed:abstractText |
The genes for the production of elloramycin (ELM) from Streptomyces olivaceus (So) Tü2353 were cloned using a polyketide synthase gene probe from the tetracenomycin pathway. A cosmid clone (16F4) isolated from a gene library of So Tü2353 conferred tetracenomycin C and ELM resistance to S. lividans TK64 and complemented a mutation in So Tü2353R. Introduction of cosmid 16F4 into S. lividans TK64 resulted in the production of 8-demethyl-tetracenomycin C, an intermediate of ELM biosynthesis.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0378-1119
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
166
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
121-6
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8529875-Anthraquinones,
pubmed-meshheading:8529875-Anti-Bacterial Agents,
pubmed-meshheading:8529875-Cloning, Molecular,
pubmed-meshheading:8529875-Cosmids,
pubmed-meshheading:8529875-Genes, Bacterial,
pubmed-meshheading:8529875-Genetic Complementation Test,
pubmed-meshheading:8529875-Multienzyme Complexes,
pubmed-meshheading:8529875-Restriction Mapping,
pubmed-meshheading:8529875-Streptomyces
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Identification of Streptomyces olivaceus Tü 2353 genes involved in the production of the polyketide elloramycin.
|
| pubmed:affiliation |
Biologisches Institut, Universität Tübingen, Germany.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|