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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0040135,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0205251,
umls-concept:C0205281,
umls-concept:C0206588,
umls-concept:C0330390,
umls-concept:C0332281,
umls-concept:C0441655,
umls-concept:C1514559,
umls-concept:C1518174,
umls-concept:C1709130,
umls-concept:C2239176,
umls-concept:C2911684
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pubmed:issue |
1
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|
pubmed:dateCreated |
1996-1-29
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|
pubmed:abstractText |
To understand the role of thyroid hormone in metastasis, we studied the expression of the anti-metastatic nm23 gene in eight human hepatocellular carcinoma (HCC) cell lines. These cells differentially expressed the anti-metastatic nm23 gene. A low level of nm23 proteins was found to have a high in vitro invasive activity which correlated closely with an overexpression of the thyroid hormone beta 1 nuclear receptor (h-TR beta 1). Concurrent with the down-regulation of h-TR beta 1, the invasive activity of HCC cells was suppressed by the thyroid hormone, 3,3',5-triiodo-L-thyronine (T3). These results indicate that the invasive activity of HCC cells was regulated by T3, suggesting that T3 could be involved in modulating the functions of nm23.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0304-3835
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
98
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
89-95
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8529211-Carcinoma, Hepatocellular,
pubmed-meshheading:8529211-Down-Regulation,
pubmed-meshheading:8529211-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8529211-Humans,
pubmed-meshheading:8529211-Liver Neoplasms,
pubmed-meshheading:8529211-Monomeric GTP-Binding Proteins,
pubmed-meshheading:8529211-NM23 Nucleoside Diphosphate Kinases,
pubmed-meshheading:8529211-Neoplasm Invasiveness,
pubmed-meshheading:8529211-Nucleoside-Diphosphate Kinase,
pubmed-meshheading:8529211-Receptors, Thyroid Hormone,
pubmed-meshheading:8529211-Transcription Factors,
pubmed-meshheading:8529211-Triiodothyronine,
pubmed-meshheading:8529211-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
Increased invasive activity of human hepatocellular carcinoma cells is associated with an overexpression of thyroid hormone beta 1 nuclear receptor and low expression of the anti-metastatic nm23 gene.
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pubmed:affiliation |
Graduate Institute of Clinical Medicine, Chang Gung College of Medicine and Technology, Kwei-san, Taoyuan-Hsien, Taiwan, Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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