Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-1-29
pubmed:abstractText
Human immunodeficiency virus type 1 (HIV-1) is a lentivirus and shares with other members of this retroviral subfamily the ability to replicate in nondividing cells, in particular, cells of the monocyte/macrophage lineage. This feature relies on the presence of a specific nuclear localization signal (NLS) within the viral matrix protein (MA p17), which to some degree can be complemented by the activity of the viral vpr gene product. The MA p17 NLS ensures efficient transportation of the viral preintegration complex into the nucleus of an infected macrophage and confers persistence of HIV-1 in quiescent T cells, and therefore presents an attractive target for therapeutic intervention.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-1347054, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-1364173, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-1386485, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-1540400, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-1556179, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-1631159, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-1661072, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-1712326, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-1714326, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-1720811, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-1738194, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-1925601, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-2162284, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-2186752, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-2200125, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-2331748, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-2508709, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-2889110, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-3013342, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-3014036, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-3014648, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-3016903, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-3018755, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-3047875, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-3258626, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-3729308, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-6690682, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-7687060, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-7903679, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8041734, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8041786, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8099628, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8105392, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8107265, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8160767, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8228347, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8251595, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8254763, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8270859, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8315356, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8356453, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8428524, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8455722, http://linkedlifedata.com/resource/pubmed/commentcorrection/8529100-8491198
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1076-1551
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-30
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.
pubmed:affiliation
Picower Institute for Medical Research, Manhasset, New York 11030, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't