Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-1-30
pubmed:abstractText
To elucidate the mechanism of development of asthma, we tried to develop a model which elicited a late asthmatic response by a combination of systemic and inhaled sensitization with ovalbumin in guinea pigs. Eighty-seven percent of animals elicited both an immediate and late asthmatic response after the third antigen inhalation. Airway eosinophilia and airway hyperresponsiveness (AHR) induced after the third challenge were more severe than those after the first challenge. There was a good correlation between airway eosinophilia and AHR in this model under experimental modulation of the number of eosinophils, such as by interleukin 5 or antieosinophil antibody injection. These results demonstrate that eosinophils play an important role in the development of late asthmatic response and AHR.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1018-2438
pubmed:author
pubmed:issnType
Print
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
86-94
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed-meshheading:8527956-Animals, pubmed-meshheading:8527956-Antibodies, pubmed-meshheading:8527956-Asthma, pubmed-meshheading:8527956-Bronchial Hyperreactivity, pubmed-meshheading:8527956-Bronchial Provocation Tests, pubmed-meshheading:8527956-Bronchoalveolar Lavage Fluid, pubmed-meshheading:8527956-Bronchoconstrictor Agents, pubmed-meshheading:8527956-Disease Models, Animal, pubmed-meshheading:8527956-Eosinophils, pubmed-meshheading:8527956-Guinea Pigs, pubmed-meshheading:8527956-Histamine, pubmed-meshheading:8527956-Interleukin-5, pubmed-meshheading:8527956-Leukocyte Count, pubmed-meshheading:8527956-Leukotriene C4, pubmed-meshheading:8527956-Male, pubmed-meshheading:8527956-Methacholine Chloride, pubmed-meshheading:8527956-Ovalbumin, pubmed-meshheading:8527956-Passive Cutaneous Anaphylaxis, pubmed-meshheading:8527956-Pulmonary Eosinophilia, pubmed-meshheading:8527956-Thromboxane B2, pubmed-meshheading:8527956-Time Factors
pubmed:year
1996
pubmed:articleTitle
Relationship between airway eosinophilia and airway hyperresponsiveness in a late asthmatic model of guinea pigs.
pubmed:affiliation
Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
pubmed:publicationType
Journal Article