Linked Life Data

8527740

Source:http://linkedlifedata.com/resource/pubmed/id/8527740

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1996-1-26
pubmed:abstractText
Systemic administration of DL-fenfluramine (20 mg kg-1), an indirect serotonergic agonist, induced widespread FOS-like protein in the rat caudate putamen (CPu), paraventricular nucleus (PVn) of the hypothalamus and several intralaminar thalamic nuclei. To ascertain whether the dopaminergic nigrostriatal system coordinated transcriptional effects on the CPu, discrete microinjections of dextran into the substantia nigra (cell group A9) were evaluated for retrograde axonal transport. The protein product was induced preferentially in medium-sized spiny nerve cells of the CPu. Dextran microinjections into the PVn demonstrated that perikarya bearing FOS-like protein projected their extensions directly to thalamic nuclei and indirectly to immunopositive neurons of the striatum. The significance of these latter results is discussed in terms of a possible dopaminergic mechanism.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1679-83
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Fenfluramine-induced c-fos in the striatum and hypothalamus: a tract-tracing study.
pubmed:affiliation
Department of Psychology, State University of New York at Buffalo 14260-4110, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.