|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
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|
pubmed:dateCreated |
1996-1-29
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|
pubmed:abstractText |
A non-covalently binding inhibitory ligand of poly(ADP-ribose) polymerase, 5-iodo-6-amino-1,2-benzopyrone, when incubated at 5-600 microM external concentration with an E-ras-transformed tumorigenic cell line or with human prostatic carcinoma cells for 40 to 60 days converts both cancer cells to a non-tumorigenic phenotype that is characterized by drastic changes in cell morphology, absence of tumorigenicity in nude mice, and a high rate of aerobic glycolysis.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0300-9084
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
77
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
374-7
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:8527492-Animals,
pubmed-meshheading:8527492-Antineoplastic Agents,
pubmed-meshheading:8527492-Cattle,
pubmed-meshheading:8527492-Cell Transformation, Neoplastic,
pubmed-meshheading:8527492-Cells, Cultured,
pubmed-meshheading:8527492-Coumarins,
pubmed-meshheading:8527492-Endothelium, Vascular,
pubmed-meshheading:8527492-Genes, ras,
pubmed-meshheading:8527492-Glycolysis,
pubmed-meshheading:8527492-Humans,
pubmed-meshheading:8527492-Ligands,
pubmed-meshheading:8527492-Male,
pubmed-meshheading:8527492-Mice,
pubmed-meshheading:8527492-Mice, Nude,
pubmed-meshheading:8527492-Phenotype,
pubmed-meshheading:8527492-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:8527492-Prostatic Neoplasms,
pubmed-meshheading:8527492-Transplantation, Heterologous,
pubmed-meshheading:8527492-Tumor Cells, Cultured
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|
pubmed:year |
1995
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|
pubmed:articleTitle |
Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase.
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|
pubmed:affiliation |
Laboratory for Environmental Toxicology and Chemistry, San Francisco State University, Tiburon, CA 94920, USA.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
