Linked Life Data

8527238

Source:http://linkedlifedata.com/resource/pubmed/id/8527238

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-1-29
pubmed:abstractText
Analysis of serial ultrathin sections of the human aortic intima detected a new cell yet to be described in the literature. These cells, which we have designated Vascular Dendritic Cells, appeared in contact with each other and with other intimal cells. Vascular dendiritic cells are characterised by ultrastructural features similar to those of dendritic cells, including a well developed smooth endoplasmic reticulum and the presence of several processes which were 3-5 or more times in excess of the size of the cell body. In areas of the normal aorta resistant to atherosclerosis, vascular dendritic cells were mainly localised in the subendothelial layer where they contacted both endothelial cells and smooth muscle cells. In areas of the normal aorta predisposed to atherosclerosis, vascular dendritic cells were distributed throughout the intima and the cellular interactions were altered with the vascular dendritic cells, developing multiple contacts with monocyte/macrophages and lymphocyte-like cells. Aortic areas predisposed to atherosclerosis showed the destruction of some vascular dendritic cell processes where they apposed endothelial cells. We speculate that vascular dendritic cells (VDCs) are a variety of dendritic cell and are involved in the maintenance of homeostasis in normal arterial intima. Vascular dendritic cells may be important in the development of atherosclerotic lesions, possibly through an immune mechanism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0914-9465
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
307-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Ultrastructural recognition of cells with dendritic cell morphology in human aortic intima. Contacting interactions of Vascular Dendritic Cells in athero-resistant and athero-prone areas of the normal aorta.
pubmed:affiliation
Surgical Professional Unit, St Vincent's Hospital, University of New South Wales, Sydney, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't