Linked Life Data

8527122

Source:http://linkedlifedata.com/resource/pubmed/id/8527122

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-1-30
pubmed:abstractText
The acceptability of viral vaccines manufactured in culture of continuous cell lines opened the way to a new technology of vaccine preparation. The large scale cultivation of continuous cell lines contributed greatly to the improvement of the safety and the consistency of viral vaccines. Experimental studies concerning residual cellular DNA and its oncogenic potential showed clearly that this material is not able to induce tumours. The small amounts of cellular DNA present in the final product, and the deleterious effect of the vaccine manufacturing process on the integrity and biological activity of DNA, both contribute to regarding residual cellular DNA as an issue of no practical importance. There is no evidence that limits on the concentration of residual cellular DNA in the final product is scientifically justified.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1045-1056
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-8
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Viral vaccines and residual cellular DNA.
pubmed:affiliation
Institut Pasteur, Paris, France.
pubmed:publicationType
Journal Article, Review