rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
12
|
pubmed:dateCreated |
1996-1-25
|
pubmed:abstractText |
Animal and human autoradiographic studies have shown increased in vitro binding of the peripheral benzodiazepine binding site antagonist PK 11195 in areas of microgliosis, including the temporal association cortex of patients with Alzheimer's disease. To further elucidate the role of cellular inflammation and microgliosis in Alzheimer's disease during life, we used PET and [11C]PK 11195, a peripheral benzodiazepine receptor ligand known to bind avidly to microglia.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0161-5505
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
36
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2207-10
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:8523106-Aged,
pubmed-meshheading:8523106-Aged, 80 and over,
pubmed-meshheading:8523106-Alzheimer Disease,
pubmed-meshheading:8523106-Brain,
pubmed-meshheading:8523106-Carbon Radioisotopes,
pubmed-meshheading:8523106-Case-Control Studies,
pubmed-meshheading:8523106-Deoxyglucose,
pubmed-meshheading:8523106-Female,
pubmed-meshheading:8523106-Fluorine Radioisotopes,
pubmed-meshheading:8523106-Fluorodeoxyglucose F18,
pubmed-meshheading:8523106-Humans,
pubmed-meshheading:8523106-Isoquinolines,
pubmed-meshheading:8523106-Male,
pubmed-meshheading:8523106-Microglia,
pubmed-meshheading:8523106-Receptors, GABA-A,
pubmed-meshheading:8523106-Tomography, Emission-Computed
|
pubmed:year |
1995
|
pubmed:articleTitle |
PET of peripheral benzodiazepine binding sites in the microgliosis of Alzheimer's disease.
|
pubmed:affiliation |
Division of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor 48109-0028, USA.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|