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pubmed-article:8523060pubmed:abstractTextMost pediatric treatment protocols specify dose calculations for cytostatic drugs based on body-surface area (BSA). However, for children less than 1 year of age, calculation guidelines vary. Normally, reduced dosages are recommended with calculations based on body weight (BW). However, the optimal dose for infants should take age-dependent and drug-specific pharmacokinetic parameters into account.lld:pubmed
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pubmed-article:8523060pubmed:articleTitleSteady-state levels and bone marrow toxicity of etoposide in children and infants: does etoposide require age-dependent dose calculation?lld:pubmed
pubmed-article:8523060pubmed:affiliationDepartment of Pediatric Hematology and Onkology, University of Münster, Germany.lld:pubmed
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