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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1996-1-22
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pubmed:abstractText |
Mosaic trisomy of chromosome 7 is known to occur in a variety of non-neoplastic hyperproliferative disorders. In long-term cell cultures established from rheumatic synovium with mosaic trisomy 7, we observed a continuous increase in the proportion of cells with trisomy 7 to over 50% by the 10th in vitro passage. Simultaneous in situ hybridization with a repetitive chromosome-7-specific DNA probe and fluorescent Ki-67 labelling showed a strong correlation between trisomy 7 and an elevated proliferation index in cultured rheumatic synovial cells. Moreover, we observed a fraction of rapidly proliferating cells with up to eight copies of chromosome 7 as the sole cytogenetic change. Frequent somatic pairing of centromeres of two chromosomes 7 in interphase nuclei suggests either atypical non-disjunction with a persisting centromere or selective endoreduplication of chromosome 7.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0340-6717
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
651-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8522321-Arthritis, Rheumatoid,
pubmed-meshheading:8522321-Cells, Cultured,
pubmed-meshheading:8522321-Chromosomes, Human, Pair 7,
pubmed-meshheading:8522321-DNA Probes,
pubmed-meshheading:8522321-Humans,
pubmed-meshheading:8522321-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8522321-Ki-67 Antigen,
pubmed-meshheading:8522321-Mosaicism,
pubmed-meshheading:8522321-Neoplasm Proteins,
pubmed-meshheading:8522321-Nuclear Proteins,
pubmed-meshheading:8522321-Synovial Membrane,
pubmed-meshheading:8522321-Trisomy
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pubmed:year |
1995
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pubmed:articleTitle |
Proliferation enhancement by spontaneous multiplication of chromosome 7 in rheumatic synovial cells in vitro.
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pubmed:affiliation |
Institut für Humangenetik, Universität des Saarlandes, Universitätskliniken Bau 68, Homburg/Saar, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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