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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1996-1-23
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pubmed:databankReference |
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pubmed:abstractText |
Vulval induction in C. elegans is controlled by a highly conserved signaling pathway similar to the RTK-Ras-MAPK cascade in mammals. By screening for suppressors of the Multivulva phenotype caused by an activated let-60 ras allele, we isolated mutations in a gene, ksr-1, that acts as a positive modifier of vulval induction and is required for at least two other let-60 ras-mediated processes. Although ksr-1 mutations do not perturb vulval induction in an otherwise wild-type background, they have very strong effects on vulval induction in genetic backgrounds where Ras pathway activity is constitutively activated or compromised, suggesting that ksr-1 activity is required for maximal stimulation of vulval fates by the Ras pathway. Genetic epistasis analysis suggests that ksr-1 acts downstream of or in parallel to let-60 ras. We cloned ksr-1 and have shown that it encodes a novel putative protein kinase related to the Raf family of Ser/Thr kinases.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
889-901
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8521513-Amino Acid Sequence,
pubmed-meshheading:8521513-Animals,
pubmed-meshheading:8521513-Base Sequence,
pubmed-meshheading:8521513-Caenorhabditis elegans,
pubmed-meshheading:8521513-Chromosome Mapping,
pubmed-meshheading:8521513-Cloning, Molecular,
pubmed-meshheading:8521513-Embryonic Induction,
pubmed-meshheading:8521513-Epistasis, Genetic,
pubmed-meshheading:8521513-Female,
pubmed-meshheading:8521513-Gene Dosage,
pubmed-meshheading:8521513-Genes, Helminth,
pubmed-meshheading:8521513-Genes, Suppressor,
pubmed-meshheading:8521513-Molecular Sequence Data,
pubmed-meshheading:8521513-Mutation,
pubmed-meshheading:8521513-Protein-Serine-Threonine Kinases,
pubmed-meshheading:8521513-Proto-Oncogene Proteins,
pubmed-meshheading:8521513-Proto-Oncogene Proteins c-raf,
pubmed-meshheading:8521513-Sequence Analysis, DNA,
pubmed-meshheading:8521513-Signal Transduction,
pubmed-meshheading:8521513-Vulva,
pubmed-meshheading:8521513-ras Proteins
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pubmed:year |
1995
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pubmed:articleTitle |
The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.
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pubmed:affiliation |
Department of Molecular, University of Colorado, Boulder 80309-0347, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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