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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-1-24
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pubmed:abstractText |
The prostaglandin endoperoxide H synthase isoform 2, cyclooxygenase 2 (COX-2), is induced at high levels in migratory and other responding cells by pro-inflammatory stimuli. COX-2 is generally considered to be a mediator of inflammation. Its isoform, COX-1, is constitutively expressed in most tissues and is thought to mediate "housekeeping" functions. These two enzymes are therapeutic targets of the widely used nonsteroidal anti-inflammatory drugs (NSAIDs). To investigate further the different physiologic roles of these isoforms, we have used homologous recombination to disrupt the mouse gene encoding COX-2 (Ptgs2). Mice lacking COX-2 have normal inflammatory responses to treatments with tetradecanoyl phorbol acetate or with arachidonic acid. However, they develop severe nephropathy and are susceptible to peritonitis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:JennetteJ CJC,
pubmed-author:KluckmanK DKD,
pubmed-author:LangenbachRR,
pubmed-author:LedfordAA,
pubmed-author:LeeC ACA,
pubmed-author:LoftinC DCD,
pubmed-author:MahlerJ FJF,
pubmed-author:MorhamS GSG,
pubmed-author:SmithiesOO,
pubmed-author:TianoH FHF,
pubmed-author:VouloumanosNN
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
473-82
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8521477-Animals,
pubmed-meshheading:8521477-Arachidonic Acid,
pubmed-meshheading:8521477-Bacteriophage lambda,
pubmed-meshheading:8521477-Base Sequence,
pubmed-meshheading:8521477-Dinoprostone,
pubmed-meshheading:8521477-Female,
pubmed-meshheading:8521477-Genetic Vectors,
pubmed-meshheading:8521477-Genotype,
pubmed-meshheading:8521477-Homozygote,
pubmed-meshheading:8521477-Kidney,
pubmed-meshheading:8521477-Lipopolysaccharides,
pubmed-meshheading:8521477-Macrophages, Peritoneal,
pubmed-meshheading:8521477-Male,
pubmed-meshheading:8521477-Mice,
pubmed-meshheading:8521477-Mice, Mutant Strains,
pubmed-meshheading:8521477-Molecular Sequence Data,
pubmed-meshheading:8521477-Mortality,
pubmed-meshheading:8521477-Otitis Externa,
pubmed-meshheading:8521477-Peritoneum,
pubmed-meshheading:8521477-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:8521477-Tetradecanoylphorbol Acetate
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pubmed:year |
1995
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pubmed:articleTitle |
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.
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pubmed:affiliation |
Department of Pathology, University of North Carolina at Chapel Hill 27599-7525, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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