Linked Life Data

8521278

Source:http://linkedlifedata.com/resource/pubmed/id/8521278

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-1-19
pubmed:abstractText
In a computational model of the bursting neuron R15, we have implemented proposed mechanisms for the modulation of two ionic currents (IR and ISI) that play key roles in regulating its spontaneous electrical activity. The model was sufficient to simulate a wide range of endogenous activity in the presence of various concentrations of serotonin (5-HT) or dopamine (DA). The model was also sufficient to simulate the responses of the neuron to extrinsic current pulses and the ways in which those responses were altered by 5-HT or DA. The results suggest that the actions of modulatory agents and second messengers on this neuron, and presumably other neurons, cannot be understood on the basis of their direct effects alone. It is also necessary to take into account the indirect effects of these agents on other unmodulated ion channels. These indirect effects occur through the dynamic interactions of voltage-dependent and calcium-dependent processes.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0929-5313
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-44
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Analysis of the effects of modulatory agents on a modeled bursting neuron: dynamic interactions between voltage and calcium dependent systems.
pubmed:affiliation
Dept. of Electrical and Computer Engineering, Rice University, Houston, TX 77251-1892, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't