Linked Life Data

8518323

Source:http://linkedlifedata.com/resource/pubmed/id/8518323

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-7-29
pubmed:abstractText
Pharmaceutical formulations often contain one or more paraben preservatives in conjunction with a polyol such as sorbitol or glycerol. In one of these experimental formulations a number of unknown polar peaks have been detected near the solvent front by reversed-phase LC. These degradation products were not attributable to the active drug component or a hydrolysis product. The possibility of an interaction between the polyols and paraben preservatives has been explored using a three-variable, two-level, factorial design to determine the relative significance of the factors involved in the formation of these unknown peaks. The factors examined were pH, temperature and the ratio of polyol to paraben. This study has shown that pH and temperature are key factors affecting the formation of these unknown peaks. On the basis of these results suitable conditions can be suggested for minimizing the production of these unknown peaks. It seems clear that a number of pharmaceutical formulations containing a polyol and a paraben would present potential problems for assay validation on storage owing to the formation of these degradation products, particularly if the drug component is polar and elutes near the solvent front.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0731-7085
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
233-40
pubmed:dateRevised
2000-12-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
LC studies on the potential interaction of paraben preservatives with sorbitol and glycerol.
pubmed:affiliation
School of Pharmacy, University of Bradford, UK.
pubmed:publicationType
Journal Article