Linked Life Data

8516368

Source:http://linkedlifedata.com/resource/pubmed/id/8516368

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-7-19
pubmed:abstractText
Effects of estrous cycle and acute and chronic access to palatable fluids on tail-flick latency and opiate-induced analgesia were assessed in 124 female Long Evans rats. Following three consistent cycles, rats were water deprived for 8 h and then given ad lib access to 20 ml of either water, a 32% sucrose solution, or corn oil for 5 h. Nociceptive testing was conducted immediately preceding and 30, 60, and 90 min following an SC injection of morphine sulfate (7.5 mg/kg). Diestrus rats had prolonged premorphine tail-flick latencies compared to rats in proestrus. Rats that consumed corn oil had longer tail-flick latencies preceding and 30 min following morphine injections than rats that drank water or the sucrose solution. Rats were retested after they had ad lib access to the same fluid for 3 weeks. No estrous cycle differences were noted following chronic consumption. Rats with chronic access to sucrose showed increased baseline pain sensitivity and increased morphine-induced analgesia at 30, 60, and 90 min postinjection. These data support the notion that palatable fluid consumption attenuates estrous cycle-dependent differences in pain sensitivity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-60
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Diet and estrous cycle influence pain sensitivity in rats.
pubmed:affiliation
Department of Psychology, Tufts University, Medford, MA 02155.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't