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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1977-4-15
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pubmed:abstractText |
The tumor suppressive activity of murine IgG1 antibody was studied in vivo. IgG1 was isolated from hyperimmune alloantisera against a murine lymphoma, 6C3HED, by absorption with heat-killed, formalinized Staphylococcus aureus. Cowan strain I, followed by DEAE ion exchange chromatography and Sephadex G-200 gel filtration chromatography. The isolated IgG1, which had no detectable IgM, IgA, IgG2a, IgG2b or IgG3, could suppress the growth of the tumor. In addition, DEAE and Sephadex G-200 column profiles of the in vivo tumor suppressive activity showed good correlation with the profiles of total IgG1 immunoglobulin and anti-tumor antibody assayed for IgG1 heavy chains and kappa light chains. The IgG1 tumor suppressive activity was not diminished after heating at 56 degrees C for 30 min.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
489-93
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:851484-Animals,
pubmed-meshheading:851484-Antibody Specificity,
pubmed-meshheading:851484-Cell Transformation, Neoplastic,
pubmed-meshheading:851484-Chromatography, Gel,
pubmed-meshheading:851484-Chromatography, Ion Exchange,
pubmed-meshheading:851484-Hot Temperature,
pubmed-meshheading:851484-Immune Sera,
pubmed-meshheading:851484-Immunoglobulin G,
pubmed-meshheading:851484-Immunosuppressive Agents,
pubmed-meshheading:851484-Isoantibodies,
pubmed-meshheading:851484-Lymphoma,
pubmed-meshheading:851484-Mice,
pubmed-meshheading:851484-Mice, Inbred C3H,
pubmed-meshheading:851484-Mice, Inbred C57BL,
pubmed-meshheading:851484-Radioimmunoassay
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pubmed:year |
1977
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pubmed:articleTitle |
Antibody-mediated suppression of tumor growth. I. Suppression by murine IgG1 isolated from alloantiserum.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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