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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
1993-7-22
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|
pubmed:abstractText |
The expression of MMP-7 (pump-1) gene was examined in 10 cases of colorectal cancer by utilizing RT-PCR. In 9 out of 10 cases, MMP-7 mRNA was detected in cancerous tissue, whereas none was detected in adjacent normal colon tissue. However, this message was detected in only 1 out of 6 colon-cancer cell lines. In colonic mucosa from 3 patients with ulcerative colitis it was not detected. The expression of MMP-2 (72-kDa type-IV collagenase) mRNA was also investigated in the same tissue samples, and was detected in all samples, including cancerous and non-cancerous tissue. Our data suggest that MMP-7 is expressed in a tumor-associated manner in colorectal cancers and may play a role in tumor progression.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0020-7136
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
54
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pubmed:geneSymbol |
pump-1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
614-8
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:8514452-Adult,
pubmed-meshheading:8514452-Aged,
pubmed-meshheading:8514452-Base Sequence,
pubmed-meshheading:8514452-Colon,
pubmed-meshheading:8514452-Colorectal Neoplasms,
pubmed-meshheading:8514452-Female,
pubmed-meshheading:8514452-Gene Expression,
pubmed-meshheading:8514452-Humans,
pubmed-meshheading:8514452-Male,
pubmed-meshheading:8514452-Matrix Metalloproteinase 2,
pubmed-meshheading:8514452-Matrix Metalloproteinase 7,
pubmed-meshheading:8514452-Metalloendopeptidases,
pubmed-meshheading:8514452-Middle Aged,
pubmed-meshheading:8514452-Molecular Sequence Data,
pubmed-meshheading:8514452-Polymerase Chain Reaction,
pubmed-meshheading:8514452-RNA, Messenger,
pubmed-meshheading:8514452-Transcription, Genetic,
pubmed-meshheading:8514452-Tumor Cells, Cultured
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pubmed:year |
1993
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pubmed:articleTitle |
Expression of MMP-7(PUMP-1) mRNA in human colorectal cancers.
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pubmed:affiliation |
Department of Internal Medicine (Section 1), School of Medicine, Sapporo Medical University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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