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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1993-7-22
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pubmed:abstractText |
Forty-three fresh tumor specimens of human neuroblastoma belonging to different clinical stages were analyzed for the expression of 2 proto-oncogenes: trk, which encodes a tyrosine-kinase receptor for nerve growth factor (NGF) and ret, another receptor-type tyrosine kinase whose ligand is unknown. The mRNA expression of the trk gene was detected in 67.4% of cases, with increased frequency in I, II and IVs Evans' stages and in patients with favorable prognosis according to the Shimada classification. Moreover, trk expression inversely correlated with Nmyc-gene amplification. ret mRNA was found in 36.8% of cases and equally distributed in the different stages. In addition, ngfR (low-affinity NGF receptor)-gene expression was present in 9 out of 25 cases. The simultaneous presence of mRNA related to both forms of the NGF receptor, while not proving the presence of a functional receptor, indicates the existence of a sub-set of neuroblastoma cells potentially responsive to NGF.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ret,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, trkA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Ret oncogene protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0020-7136
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
54
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pubmed:geneSymbol |
ret,
trk
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
540-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8514446-Adolescent,
pubmed-meshheading:8514446-Adult,
pubmed-meshheading:8514446-Base Sequence,
pubmed-meshheading:8514446-Child,
pubmed-meshheading:8514446-Child, Preschool,
pubmed-meshheading:8514446-DNA, Neoplasm,
pubmed-meshheading:8514446-Drosophila Proteins,
pubmed-meshheading:8514446-Gene Expression,
pubmed-meshheading:8514446-Humans,
pubmed-meshheading:8514446-Infant,
pubmed-meshheading:8514446-Infant, Newborn,
pubmed-meshheading:8514446-Molecular Sequence Data,
pubmed-meshheading:8514446-Nerve Growth Factors,
pubmed-meshheading:8514446-Neuroblastoma,
pubmed-meshheading:8514446-Polymerase Chain Reaction,
pubmed-meshheading:8514446-Proto-Oncogene Proteins,
pubmed-meshheading:8514446-Proto-Oncogene Proteins c-ret,
pubmed-meshheading:8514446-Proto-Oncogenes,
pubmed-meshheading:8514446-RNA, Messenger,
pubmed-meshheading:8514446-RNA, Neoplasm,
pubmed-meshheading:8514446-Receptor, trkA,
pubmed-meshheading:8514446-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:8514446-Survival Analysis,
pubmed-meshheading:8514446-Transcription, Genetic
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pubmed:year |
1993
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pubmed:articleTitle |
trk and ret proto-oncogene expression in human neuroblastoma specimens: high frequency of trk expression in non-advanced stages.
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pubmed:affiliation |
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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