Linked Life Data

8514132

Source:http://linkedlifedata.com/resource/pubmed/id/8514132

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pubmed-article:8514132pubmed:abstractTextIn the T(1;2)dorvar7 translocation, the 1A-2B7-8 segment of the X chromosome is brought to the vicinity of 2R-chromosome heterochromatin resulting in position effect variegation of dor, BR-C and more distal genes, as well as compaction of chromatin in this segment. By irradiation of T(1;2)dorvar7, nine reversions (rev) to a normal phenotype were recovered. In two cases (rev27, rev226), the 1A-2B7-8 section is relocated to the 19A region of the X chromosome, forming free duplications (1A-2B7-8/19A-20F-X-het). Modifiers of position effect do not change the normal expression of the BR-C and dor genes in these duplications. In five reversions (rev3, rev40, rev60, rev167, rev175), free duplications have formed from the 1A-2B7-8 fragment and X chromosome heterochromatin. In these rearrangements, modifiers of position effect (low temperature, removal of Y and 2R-chromosome heterochromatin and a genetic enhancer (E-var(3)201) induce position-effect again. Two reversions (rev45 and rev110) are associated with additional inversions in the original dorvar7 chromosomes. The inversions relocate part of the heterochromatin adjacent to the 1A-2B7-8 section into new positions. In T(1;2)dorrev45, position-effect is seen in the 2B7-8-7A element as compaction spreading from 2B7-8 proximally in some cases as far as the 5D region. Thus, in rev45 the pattern of euchromatin compaction is reciprocal to that of the initial dorvar7 strain. Apparently, it is due to the same variegation-evoking center near the 2R centromere in both cases. In all nine revertants, weakening or complete disappearance of the position-effect is observed despite retention of the 20-kb heterochromatic segment adjacent to the 1A-2B7-8 region. Thus, a 20-kb heterochromatic sequence does not inactivate euchromatin joined to it.lld:pubmed
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pubmed-article:8514132pubmed:authorpubmed-author:ZhimulevI FIFlld:pubmed
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pubmed-article:8514132pubmed:pagination231-42lld:pubmed
pubmed-article:8514132pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:8514132pubmed:articleTitleObservations on the induction of position effect variegation of euchromatic genes in Drosophila melanogaster.lld:pubmed
pubmed-article:8514132pubmed:affiliationInstitute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk.lld:pubmed
pubmed-article:8514132pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8514132pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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