Linked Life Data

8514132

Source:http://linkedlifedata.com/resource/pubmed/id/8514132

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-7-20
pubmed:abstractText
In the T(1;2)dorvar7 translocation, the 1A-2B7-8 segment of the X chromosome is brought to the vicinity of 2R-chromosome heterochromatin resulting in position effect variegation of dor, BR-C and more distal genes, as well as compaction of chromatin in this segment. By irradiation of T(1;2)dorvar7, nine reversions (rev) to a normal phenotype were recovered. In two cases (rev27, rev226), the 1A-2B7-8 section is relocated to the 19A region of the X chromosome, forming free duplications (1A-2B7-8/19A-20F-X-het). Modifiers of position effect do not change the normal expression of the BR-C and dor genes in these duplications. In five reversions (rev3, rev40, rev60, rev167, rev175), free duplications have formed from the 1A-2B7-8 fragment and X chromosome heterochromatin. In these rearrangements, modifiers of position effect (low temperature, removal of Y and 2R-chromosome heterochromatin and a genetic enhancer (E-var(3)201) induce position-effect again. Two reversions (rev45 and rev110) are associated with additional inversions in the original dorvar7 chromosomes. The inversions relocate part of the heterochromatin adjacent to the 1A-2B7-8 section into new positions. In T(1;2)dorrev45, position-effect is seen in the 2B7-8-7A element as compaction spreading from 2B7-8 proximally in some cases as far as the 5D region. Thus, in rev45 the pattern of euchromatin compaction is reciprocal to that of the initial dorvar7 strain. Apparently, it is due to the same variegation-evoking center near the 2R centromere in both cases. In all nine revertants, weakening or complete disappearance of the position-effect is observed despite retention of the 20-kb heterochromatic segment adjacent to the 1A-2B7-8 region. Thus, a 20-kb heterochromatic sequence does not inactivate euchromatin joined to it.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-1914664, http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-2087785, http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-2090429, http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-2118871, http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-2124708, http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-2515045, http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-2515059, http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-3123888, http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-4117921, http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-5888666, http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-6086148, http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-6193889, http://linkedlifedata.com/resource/pubmed/commentcorrection/8514132-98264
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
231-42
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Observations on the induction of position effect variegation of euchromatic genes in Drosophila melanogaster.
pubmed:affiliation
Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't