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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1993-7-20
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pubmed:abstractText |
Activity of stimulatory GTP-binding regulatory protein (Gs) in human erythrocyte membranes was assessed by activation of adenylate cyclase in S49 murine lymphoma variant cells to elucidate a relationship to alcohol consumption. In apparently healthy subjects, alcohol consumption < 50 g ethanol per week did not alter the Gs activity, but it was significantly higher (14.3%, P < 0.05) in moderate drinkers (50-150 g/week) than non-drinkers. Then, the Gs activity declined with a further increase in alcohol consumption (150-550 g/week). Those subjects with drinking levels of > 50 g/week also showed significant increases in other alcohol-related markers, Na+, K(+)-ATPase and gamma-glutamyltransferase. The Gs activity was significantly low in alcoholics (a 34.9% reduction). No such reduction was noted in patients with other diseases. The results indicate that the Gs activity in erythrocyte membranes is an alcohol-related marker in humans. The variation of Gs activity is distinctive from those of other alcohol-related markers.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0009-8981
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
215
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8513561-Adenylate Cyclase,
pubmed-meshheading:8513561-Adult,
pubmed-meshheading:8513561-Alcohol Drinking,
pubmed-meshheading:8513561-Animals,
pubmed-meshheading:8513561-Enzyme Activation,
pubmed-meshheading:8513561-Erythrocyte Membrane,
pubmed-meshheading:8513561-Female,
pubmed-meshheading:8513561-GTP-Binding Proteins,
pubmed-meshheading:8513561-Humans,
pubmed-meshheading:8513561-Lymphoma,
pubmed-meshheading:8513561-Male,
pubmed-meshheading:8513561-Mice,
pubmed-meshheading:8513561-Middle Aged
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pubmed:year |
1993
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pubmed:articleTitle |
Relationship between alcohol consumption and the activity of GTP-binding regulatory proteins in human erythrocyte membranes.
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pubmed:affiliation |
Institute of Clinical Medicine, University of Tsukuba, Japan.
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pubmed:publicationType |
Journal Article
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