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rdf:type |
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lifeskim:mentions |
umls-concept:C0009015,
umls-concept:C0014834,
umls-concept:C0017262,
umls-concept:C0079429,
umls-concept:C0185117,
umls-concept:C0217052,
umls-concept:C0679058,
umls-concept:C0995786,
umls-concept:C1547699,
umls-concept:C1561491,
umls-concept:C2700640,
umls-concept:C2911684
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pubmed:issue |
12
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pubmed:dateCreated |
1993-7-13
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pubmed:databankReference |
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pubmed:abstractText |
Sequence analysis of a portion of the Streptomyces peucetius daunorubicin biosynthetic gene cluster revealed a complete open reading frame (dnrK) that showed DNA and protein sequence homology to several O-methyltransferases. Expression of dnrK in Streptomyces lividans and Escherichia coli was done to show that this gene codes for carminomycin 4-O-methyltransferase. The deduced carminomycin 4-O-methyltransferase protein shows a conserved nucleotide binding site for its S-adenosyl-L-methionine cofactor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-14090569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-14142092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-1548230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-1729206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-1840640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-1924314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-2345153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-2681144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-2684970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-2717612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-2985470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-3029594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-3156376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-3534792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-3611052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-3818627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-3857464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-3859358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-5365804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-6096212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8509343-6546423
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
175
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pubmed:geneSymbol |
dnrK
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3900-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8509343-Amino Acid Sequence,
pubmed-meshheading:8509343-Base Sequence,
pubmed-meshheading:8509343-Cloning, Molecular,
pubmed-meshheading:8509343-Consensus Sequence,
pubmed-meshheading:8509343-Escherichia coli,
pubmed-meshheading:8509343-Genes, Bacterial,
pubmed-meshheading:8509343-Methyltransferases,
pubmed-meshheading:8509343-Molecular Sequence Data,
pubmed-meshheading:8509343-Restriction Mapping,
pubmed-meshheading:8509343-Sequence Alignment,
pubmed-meshheading:8509343-Streptomyces
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pubmed:year |
1993
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pubmed:articleTitle |
Cloning and sequencing of a gene encoding carminomycin 4-O-methyltransferase from Streptomyces peucetius and its expression in Escherichia coli.
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pubmed:affiliation |
School of Pharmacy, University of Wisconsin-Madison 53706.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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