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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1993-7-9
|
| pubmed:abstractText |
We have established a metastatic model of human gastric cancer using orthotopic transplantation of histologically intact tissue in nude mice, and have used this model to evaluate the effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) against SC-I-NU, a human stomach cancer line. One-quarter or one-half maximum tolerated doses (MTDs) of 5-FU or MMC resulted in a significant reduction of stomach tumor growth, while liver metastases were not reduced, possibly due to suppression of natural killer (NK)-cell activity by both drugs. On the other hand, when combined with OK-432, half MTDs of 5-FU and MMC significantly reduced liver metastases, with synergistic reduction of stomach tumor growth, possibly reflecting a rescue of NK-cell activity by treatment with OK-432. This metastatic model of human stomach cancer shows that locally growing and metastatic tumors may have different chemosensitivities, and provides the opportunity to test both with various treatment regimens.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
28
|
| pubmed:volume |
54
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
397-401
|
| pubmed:dateRevised |
2007-7-24
|
| pubmed:meshHeading |
pubmed-meshheading:8509214-Adenocarcinoma,
pubmed-meshheading:8509214-Animals,
pubmed-meshheading:8509214-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:8509214-Cell Count,
pubmed-meshheading:8509214-Combined Modality Therapy,
pubmed-meshheading:8509214-Disease Models, Animal,
pubmed-meshheading:8509214-Drug Screening Assays, Antitumor,
pubmed-meshheading:8509214-Fluorouracil,
pubmed-meshheading:8509214-Humans,
pubmed-meshheading:8509214-Immunotherapy,
pubmed-meshheading:8509214-Killer Cells, Natural,
pubmed-meshheading:8509214-Liver Neoplasms, Experimental,
pubmed-meshheading:8509214-Male,
pubmed-meshheading:8509214-Mice,
pubmed-meshheading:8509214-Mice, Inbred BALB C,
pubmed-meshheading:8509214-Mice, Nude,
pubmed-meshheading:8509214-Mitomycin,
pubmed-meshheading:8509214-Neoplasm Transplantation,
pubmed-meshheading:8509214-Picibanil,
pubmed-meshheading:8509214-Spleen,
pubmed-meshheading:8509214-Stomach Neoplasms,
pubmed-meshheading:8509214-Transplantation, Heterologous
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Differential chemosensitivity of local and metastatic human gastric cancer after orthotopic transplantation of histologically intact tumor tissue in nude mice.
|
| pubmed:affiliation |
Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|