Linked Life Data

8507191

Source:http://linkedlifedata.com/resource/pubmed/id/8507191

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-7-2
pubmed:abstractText
The periodic behaviour of glucose-stimulated insulin release was studied using islets isolated from ob/ob-mice and rats. A single islet was perifused at a rate of 150 microliters/min and insulin measured in samples of the medium taken at intervals as short as 3 s. Exposure to 11 mM glucose resulted in intermittent insulin release, implying that previously observed 2-3 min cycles of secretion could be resolved into regularly occurring fast (< 25 s) transients. A further raise of glucose to 20 mM was associated with increase of the amplitudes of the transients leaving their frequencies unaffected. The discovery of the insulin transients raises the question whether there is a quantal release of the hormone in response to glucose-induced rapid oscillations of cytoplasmic Ca2+ in the pancreatic beta-cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
192
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1182-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Glucose-induced cycles of insulin release can be resolved into distinct periods of secretory activity.
pubmed:affiliation
Department of Medical Cell Biology, Uppsala University, Sweden.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't