| pubmed-article:8502116 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8502116 | lifeskim:mentions | umls-concept:C0038317 | lld:lifeskim |
| pubmed-article:8502116 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:8502116 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:8502116 | lifeskim:mentions | umls-concept:C1519020 | lld:lifeskim |
| pubmed-article:8502116 | lifeskim:mentions | umls-concept:C0011185 | lld:lifeskim |
| pubmed-article:8502116 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8502116 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:8502116 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:8502116 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:8502116 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:8502116 | pubmed:dateCreated | 1993-7-1 | lld:pubmed |
| pubmed-article:8502116 | pubmed:abstractText | Dehydroepiandrosterone (DHEA) is known to induce peroxisome proliferation and peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase (PBE) mRNA in the rat liver. We have compared the effects of 6 intermediate metabolites of DHEA on the induction of peroxisome proliferation and PBE mRNA. Administration of epiandrosterone, etiocholanolone, androstenedione, estrone or estradiol for 2 weeks in the diet at 0.45% concentration to adult male F-344 rats failed to induce significant increases in peroxisome proliferation and PBE mRNA when compared to the parent compound DHEA. Dietary administration of 5-androstene-3 beta,17 beta-diol (ADIOL) for 2 weeks at 0.45% concentration caused an increase in PBE mRNA and peroxisome proliferation but to a lesser extent than DHEA. Following a single intragastric dose of DHEA an increase in PBE mRNA level was observed in the liver at 1 hr and continued to 16 hrs., but not with its metabolites. These results strongly suggest that DHEA or possibly another yet to be identified metabolite might be responsible for peroxisome proliferation. | lld:pubmed |
| pubmed-article:8502116 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8502116 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8502116 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8502116 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8502116 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8502116 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8502116 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8502116 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8502116 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8502116 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8502116 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8502116 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8502116 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8502116 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8502116 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:8502116 | pubmed:author | pubmed-author:RaoM SMS | lld:pubmed |
| pubmed-article:8502116 | pubmed:author | pubmed-author:IdeHH | lld:pubmed |
| pubmed-article:8502116 | pubmed:author | pubmed-author:ReddyJ KJK | lld:pubmed |
| pubmed-article:8502116 | pubmed:author | pubmed-author:HechterOO | lld:pubmed |
| pubmed-article:8502116 | pubmed:author | pubmed-author:AlvarezPP | lld:pubmed |
| pubmed-article:8502116 | pubmed:author | pubmed-author:SubbaraoVV | lld:pubmed |
| pubmed-article:8502116 | pubmed:author | pubmed-author:YeldandiA VAV | lld:pubmed |
| pubmed-article:8502116 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8502116 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:8502116 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8502116 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8502116 | pubmed:pagination | 1709-16 | lld:pubmed |
| pubmed-article:8502116 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:meshHeading | pubmed-meshheading:8502116-... | lld:pubmed |
| pubmed-article:8502116 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8502116 | pubmed:articleTitle | Comparative effects of dehydroepiandrosterone and related steroids on peroxisome proliferation in rat liver. | lld:pubmed |
| pubmed-article:8502116 | pubmed:affiliation | Department of Pathology, Northwestern University Medical School, Chicago, IL 60611. | lld:pubmed |
| pubmed-article:8502116 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8502116 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8502116 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8502116 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8502116 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
