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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1993-7-1
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pubmed:abstractText |
Dehydroepiandrosterone (DHEA) is known to induce peroxisome proliferation and peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase (PBE) mRNA in the rat liver. We have compared the effects of 6 intermediate metabolites of DHEA on the induction of peroxisome proliferation and PBE mRNA. Administration of epiandrosterone, etiocholanolone, androstenedione, estrone or estradiol for 2 weeks in the diet at 0.45% concentration to adult male F-344 rats failed to induce significant increases in peroxisome proliferation and PBE mRNA when compared to the parent compound DHEA. Dietary administration of 5-androstene-3 beta,17 beta-diol (ADIOL) for 2 weeks at 0.45% concentration caused an increase in PBE mRNA and peroxisome proliferation but to a lesser extent than DHEA. Following a single intragastric dose of DHEA an increase in PBE mRNA level was observed in the liver at 1 hr and continued to 16 hrs., but not with its metabolites. These results strongly suggest that DHEA or possibly another yet to be identified metabolite might be responsible for peroxisome proliferation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1709-16
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8502116-3-Hydroxyacyl CoA Dehydrogenases,
pubmed-meshheading:8502116-Androstenedione,
pubmed-meshheading:8502116-Androsterone,
pubmed-meshheading:8502116-Animals,
pubmed-meshheading:8502116-Blotting, Northern,
pubmed-meshheading:8502116-Dehydroepiandrosterone,
pubmed-meshheading:8502116-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:8502116-Enoyl-CoA Hydratase,
pubmed-meshheading:8502116-Estradiol,
pubmed-meshheading:8502116-Estrone,
pubmed-meshheading:8502116-Etiocholanolone,
pubmed-meshheading:8502116-Liver,
pubmed-meshheading:8502116-Male,
pubmed-meshheading:8502116-Microbodies,
pubmed-meshheading:8502116-RNA, Messenger,
pubmed-meshheading:8502116-Rats,
pubmed-meshheading:8502116-Rats, Inbred F344
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pubmed:year |
1993
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pubmed:articleTitle |
Comparative effects of dehydroepiandrosterone and related steroids on peroxisome proliferation in rat liver.
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pubmed:affiliation |
Department of Pathology, Northwestern University Medical School, Chicago, IL 60611.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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