Linked Life Data

8500346

Source:http://linkedlifedata.com/resource/pubmed/id/8500346

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
292
pubmed:dateCreated
1993-6-25
pubmed:abstractText
The effects of colon mitosis inhibitor (CMI), thyroliberin (TRH), and the somatostatin analogue octreotide (SMS 201-995) on rat colonic mucosal epithelial cell proliferation were studied. As an index of cell proliferation the incorporation of bromodeoxyuridine (BrDU) into cell nuclei was used. It was found that all three peptides inhibited the colonic mucosal epithelial cells proliferation, but the time course of inhibition was different. The effect of SMS 201-995 occurred 12 h after the peptide injection, while CMI and TRH suppressed the proliferation after 24 h. These observations suggest that the mechanisms of the antiproliferative actions of somatostatin and of related tripeptides CMI and TRH are different.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0011-4529
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Comparison of the antiproliferative effects of colon mitosis inhibitor, thyroliberin and the somatostatin analog octreotide on rat colonic mucosal epithelial cells.
pubmed:affiliation
Department of Experimental Endocrinology and Hormone Diagnostics, Medical University of Lodz, Poland.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't