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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1993-6-28
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pubmed:abstractText |
Pregnant SWV mice were treated on day 9 of gestation (PC) with 50 mg/kg of caffeine (CAFF), 200 mg/kg (LD) or 1000 mg/kg (HD) of acetazolamide (ACZM), or a combination of both agents, or on day 8 PC with both agents (ACZM + CAFF). Untreated (UNTD) and vehicle-treated (VEH) groups served as controls. The SWV strain is widely reported to be resistant to ACZM; it was resistant to ACZM or CAFF + ACZM when treated on day 9 of gestation, but a significant frequency of malformations, primarily exencephaly, was produced by ACZM + CAFF on day 8 PC. This study provides evidence that ACZM, coupled with a subteratogenic dose of caffeine can produce abnormalities in the "resistant" SWV mice, using the endpoint of exencephaly on day 8 of gestation. The mean number of ossified caudal vertebrae in day-9 treatments and ossified cervical vertebral centra in day-8 treatments were reduced. The frequency of ossification of the first cervical vertebra (C1) was reduced from 93% in UNTD to 39% in HD-ACZM day 9 PC and 69% in HD-ACZM + CAFF day 9 PC groups, and was also significantly reduced in the HD-ACZM + CAFF day-8 treated group.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0890-6238
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8499663-Acetazolamide,
pubmed-meshheading:8499663-Animals,
pubmed-meshheading:8499663-Birth Weight,
pubmed-meshheading:8499663-Brain,
pubmed-meshheading:8499663-Caffeine,
pubmed-meshheading:8499663-Cervical Vertebrae,
pubmed-meshheading:8499663-Embryo, Mammalian,
pubmed-meshheading:8499663-Female,
pubmed-meshheading:8499663-Fetal Death,
pubmed-meshheading:8499663-Litter Size,
pubmed-meshheading:8499663-Mice,
pubmed-meshheading:8499663-Mice, Inbred Strains,
pubmed-meshheading:8499663-Osteogenesis,
pubmed-meshheading:8499663-Pregnancy
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pubmed:year |
1993
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pubmed:articleTitle |
Acetazolamide with caffeine causes exencephaly in "resistant" SWV mice.
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pubmed:affiliation |
Biology Department, DePaul University, Chicago, Illinois 60614.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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