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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1993-6-30
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pubmed:abstractText |
Immune activation is often accompanied by profound alterations in neurological and endocrine function, such as fever, increased somnolence, decreased appetite, activation of the hypothalamic-pituitary-adrenal axis, and suppression of the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-thyroid axes. These well-recognized systemic responses to injury and infection have been attributed to circulating pro-inflammatory cytokines, the best characterized of which is interleukin 1 (IL-1). Here Emmett Cunningham and Errol De Souza discuss the mechanisms by which blood-borne IL-1 might affect such changes in the nervous and neuroendocrine systems.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0167-5699
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
171-6
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pubmed:dateRevised |
2005-11-16
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pubmed:meshHeading |
pubmed-meshheading:8499077-Animals,
pubmed-meshheading:8499077-Brain Chemistry,
pubmed-meshheading:8499077-Female,
pubmed-meshheading:8499077-Fever,
pubmed-meshheading:8499077-Humans,
pubmed-meshheading:8499077-Hypothalamo-Hypophyseal System,
pubmed-meshheading:8499077-Interleukin-1,
pubmed-meshheading:8499077-Male,
pubmed-meshheading:8499077-Mice,
pubmed-meshheading:8499077-Neuroimmunomodulation,
pubmed-meshheading:8499077-Neurons,
pubmed-meshheading:8499077-Neurosecretory Systems,
pubmed-meshheading:8499077-Ovary,
pubmed-meshheading:8499077-Rats,
pubmed-meshheading:8499077-Receptors, Interleukin-1,
pubmed-meshheading:8499077-Signal Transduction,
pubmed-meshheading:8499077-Testis
|
pubmed:year |
1993
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pubmed:articleTitle |
Interleukin 1 receptors in the brain and endocrine tissues.
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pubmed:affiliation |
Dept of Ophthalmology, University of California, School of Medicine, San Francisco 94143.
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pubmed:publicationType |
Journal Article,
Review
|