Linked Life Data

8495708

Source:http://linkedlifedata.com/resource/pubmed/id/8495708

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-6-24
pubmed:abstractText
In recent studies, we have shown that administration of androgens to male hamsters enhances functional recovery from facial paralysis induced by facial nerve crush at the level of the stylomastoid foramen. Furthermore, we have established that the mechanism behind this enhancement of regeneration involves an acceleration of the rate of regeneration, without a shortening in the delay of sprout formation. From those studies, several unexpected findings of inherent sex differences emerged. First, intact (nongonadectomized) females have a faster facial nerve regeneration rate than males and, second, testosterone has a less dramatic effect on the rate of regeneration in females compared to males. In the present study, we explored these novel findings of sex differences in the response of motor neurons to injury. Adult intact female hamsters were subjected to right facial nerve crush axotomy at the level of stylomastoid foramen and either implanted with two or four silastic capsules containing 5 alpha-dihydrotestosterone, or sham-implanted for controls. A group of adult intact male hamsters was also subjected to right facial nerve crush axotomy. Animals were observed daily, beginning on Day 1 postoperatively and continuing throughout a 3-week recovery period for signs of functional recovery from facial paralysis. The average day of return of each of four behavioral components (semi-blink, blink reflex, full vibrissae movement, and complete recovery) was calculated for all four experimental groups. The results indicate that intact females recover functional return of movement following crush injury significantly faster than intact males. In contrast to our previous findings in male hamsters, administration of exogenous steroids does not accelerate recovery from facial paralysis in adult female hamsters.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
121
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Recovery from facial paralysis following crush injury of the facial nerve in hamsters: differential effects of gender and androgen exposure.
pubmed:affiliation
Department of Physical Therapy, University of Illinois, Chicago 60612.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.