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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1993-6-11
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pubmed:abstractText |
Nine patients with lower respiratory tract infections were used to study in detail the effect of ampicillin or erythromycin on the colonization patterns of Haemophilus influenzae and Haemophilus parainfluenzae in sputum and saliva. H. influenzae was isolated from purulent sputum of eight patients before the start of treatment. Ampicillin was more effective than erythromycin at clearing H. influenzae from sputum and in decreasing purulence. By careful characterization of multiple strains, the changes in biotype distribution and antibiotic susceptibility patterns were shown. Five biotypes of H. influenzae were associated with chest infection, with type II predominating. Mixed biotype infections occurred in five patients. Most saliva contained multiple biotypes of H. parainfluenzae. Neither antibiotic selected resistant haemophili in saliva or sputum. After treatment with ampicillin, the mucoid sputum was colonized with ampicillin-susceptible H. parainfluenzae biotypes previously found in saliva. We postulate that as inflammation decreases at the bronchial mucosa, the ampicillin concentration drops, allowing ampicillin-susceptible oral H. parainfluenzae isolates to seed the residual mucoid sputum.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-1066093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-13047351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-18077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-2313130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-2499609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-2994802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-3090858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-3258860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-3547567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-3700628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-3767348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-4163776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-4318047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-5505020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-6136690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-6332018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-6337988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-6603468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-6816135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-6968574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-6984048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-7103442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-7173170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-7287601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-7333990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-73690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494378-7429004
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
804-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8494378-Ampicillin,
pubmed-meshheading:8494378-Anti-Bacterial Agents,
pubmed-meshheading:8494378-Erythromycin,
pubmed-meshheading:8494378-Haemophilus,
pubmed-meshheading:8494378-Haemophilus Infections,
pubmed-meshheading:8494378-Haemophilus influenzae,
pubmed-meshheading:8494378-Humans,
pubmed-meshheading:8494378-Lung Diseases, Obstructive,
pubmed-meshheading:8494378-Microbial Sensitivity Tests,
pubmed-meshheading:8494378-Respiratory Tract Infections,
pubmed-meshheading:8494378-Saliva,
pubmed-meshheading:8494378-Sputum
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pubmed:year |
1993
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pubmed:articleTitle |
Ecology of Haemophilus influenzae and Haemophilus parainfluenzae in sputum and saliva and effects of antibiotics on their distribution in patients with lower respiratory tract infections.
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pubmed:affiliation |
Department of Microbiology, University of Leeds, United Kingdom.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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