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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5111
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pubmed:dateCreated |
1993-6-16
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pubmed:databankReference |
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pubmed:abstractText |
A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was purified and cloned. Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake. These effects were relatively specific; GDNF did not increase total neuron or astrocyte numbers nor did it increase transmitter uptake by gamma-aminobutyric-containing and serotonergic neurons. GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
260
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pubmed:geneSymbol |
GDNF
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1130-2
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:8493557-Amino Acid Sequence,
pubmed-meshheading:8493557-Animals,
pubmed-meshheading:8493557-Astrocytes,
pubmed-meshheading:8493557-Base Sequence,
pubmed-meshheading:8493557-Cell Differentiation,
pubmed-meshheading:8493557-Cell Line,
pubmed-meshheading:8493557-Cell Survival,
pubmed-meshheading:8493557-Cells, Cultured,
pubmed-meshheading:8493557-Cloning, Molecular,
pubmed-meshheading:8493557-Dopamine,
pubmed-meshheading:8493557-Glial Cell Line-Derived Neurotrophic Factor,
pubmed-meshheading:8493557-Humans,
pubmed-meshheading:8493557-Mesencephalon,
pubmed-meshheading:8493557-Molecular Sequence Data,
pubmed-meshheading:8493557-Molecular Weight,
pubmed-meshheading:8493557-Nerve Growth Factors,
pubmed-meshheading:8493557-Nerve Tissue Proteins,
pubmed-meshheading:8493557-Neuroglia,
pubmed-meshheading:8493557-Neurons,
pubmed-meshheading:8493557-Parkinson Disease,
pubmed-meshheading:8493557-Rats
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pubmed:year |
1993
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pubmed:articleTitle |
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.
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pubmed:affiliation |
Synergen, Inc., Boulder, CO 80301.
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pubmed:publicationType |
Journal Article,
Comment
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