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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1977-5-25
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pubmed:abstractText |
The ability of the uncharged open-coil dextran molecules to penetrate tissue space, without coil-shape change, was utilized to probe (by partitioning experiments) the structural arrangement of the collagen-fibre network and the proteoglycan system. Hyaluronidase digests most of the proteoglycans away and enables the respective contributions to the exclusion volume to be evaluated by using a series of different-molecular-weight dextrans. It appears that the major part of the exclusion volume is due to the collagen-fibril as a rod and the dextran coil as an impenetrable sphere. The additional exclusion due to the proteoglycans could be accounted for by a set of points (regions of high proteoglycan-segment density) over which the dextran coild cannot pass. These points are an average of 50 nm apart and are indicative of local extensive entanglement of high-molecular-weight proteoglycans with each other. Reasons are given why these entanglements could not act as cross-links in long-term elastic loading of the tissue.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/849263-4221469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/849263-4245322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/849263-4373638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/849263-4686200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/849263-5654612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/849263-5669847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/849263-5807216
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pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0264-6021
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
|
pubmed:volume |
161
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
285-91
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:849263-Connective Tissue,
pubmed-meshheading:849263-Dextrans,
pubmed-meshheading:849263-Humans,
pubmed-meshheading:849263-Hyaluronoglucosaminidase,
pubmed-meshheading:849263-Macromolecular Substances,
pubmed-meshheading:849263-Proteoglycans,
pubmed-meshheading:849263-Umbilical Cord
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pubmed:year |
1977
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pubmed:articleTitle |
Structural investigation of loose connective tissue by using a series of dextran fractions as non-interacting macromolecular probes.
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pubmed:publicationType |
Journal Article
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