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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1993-6-15
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pubmed:abstractText |
Thirty two patients with Helicobacter pylori positive duodenal ulcers resistant to treatment were randomly assigned to 4 weeks' treatment with sucralphate 4 g/day or colloidal bismuth subcitrate 480 mg/day plus amoxycillin from days 1 to 7 and tinidazole from days 8 to 14. After 4 weeks, patients with unhealed ulcers were crossed over to the other form of treatment for a further 4 week period. Patients with healed ulcers were followed up for 1 year without maintenance therapy with clinical and endoscopic investigations 3, 6, and 12 months after healing. Complete healing rates at 4 weeks were 88% (15 of 17) in the colloidal bismuth subcitrate plus antibiotics group and 40% (six of 15) in the sucralphate group (p < 0.05). After cross over, overall healing rates were 88% (22 of 25) and 47% (eight of 17), respectively (p < 0.05). H pylori eradication occurred in 83% of patients treated with the triple therapy. Cumulative relapse rates at 12 months were 12% (two of 17) in patients in whom H pylori had been eradicated and 100% (10 of 10) in those with persistent infection after short term therapy (p < 0.05). These results show that a colloidal bismuth subcitrate plus antibiotics regimen is highly effective in the short term treatment of resistant duodenal ulcers and that H pylori eradication can change the natural tendency to early recurrence of these ulcers.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-1347278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-1673953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-1732120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-1854110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-1971318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-1974027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-1983325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-2859501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-2870370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-2885503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-2900584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-2904568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-2908747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-3308650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-3410170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-6376292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-6428982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-6822322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-8244159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8491391-8244161
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0017-5749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
466-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8491391-Adult,
pubmed-meshheading:8491391-Aged,
pubmed-meshheading:8491391-Amoxicillin,
pubmed-meshheading:8491391-Anti-Bacterial Agents,
pubmed-meshheading:8491391-Anti-Ulcer Agents,
pubmed-meshheading:8491391-Drug Therapy, Combination,
pubmed-meshheading:8491391-Duodenal Ulcer,
pubmed-meshheading:8491391-Female,
pubmed-meshheading:8491391-Follow-Up Studies,
pubmed-meshheading:8491391-Helicobacter Infections,
pubmed-meshheading:8491391-Helicobacter pylori,
pubmed-meshheading:8491391-Humans,
pubmed-meshheading:8491391-Male,
pubmed-meshheading:8491391-Middle Aged,
pubmed-meshheading:8491391-Organometallic Compounds,
pubmed-meshheading:8491391-Sucralfate,
pubmed-meshheading:8491391-Tinidazole
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pubmed:year |
1993
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pubmed:articleTitle |
Short and long term outcome of Helicobacter pylori positive resistant duodenal ulcers treated with colloidal bismuth subcitrate plus antibiotics or sucralfate alone.
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pubmed:affiliation |
Gastrointestinal Unit, L Sacco Hospital, Milan, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
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