Linked Life Data

8491263

Source:http://linkedlifedata.com/resource/pubmed/id/8491263

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-6-16
pubmed:abstractText
We have investigated the electrophysiological effects of nerve growth factor (NGF) on single-neuron activity in central nervous system (CNS) grafts of septum, spinal cord, and hippocampus in oculo. NGF was found to have slow-onset, long-lasting excitatory effects on the spontaneous firing of neurons in septal grafts, while no such effects were found in neurons of either hippocampal or spinal cord grafts. Pretreatment with an antibody against the p75 low-affinity NGF receptor blocked the NGF-induced excitations. A second NGF application caused much stronger excitatory responses in sensitive neurons. Our data suggest that forebrain cholinergic neurons may be selectively sensitive to NGF also at the neurophysiological level, responding by excitations, and that NGF upregulates these responses within less than an hour.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0014-4819
pubmed:author
pubmed:issnType
Print
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
226-30
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Nerve growth factor-induced excitation of selected neurons in the brain which is blocked by a low-affinity receptor antibody.
pubmed:affiliation
Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't