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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-6-11
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pubmed:abstractText |
We have performed mRNA in situ hybridization studies and northern blot analysis in the mouse and human, respectively, to determine the normal gene expression patterns of FMR-1. Expression in the adult mouse was localized to several regions of the brain and the tubules of the testes, which are two of the major organs affected in fragile X syndrome. Universal and very strong expression was observed in early mouse embryos, with differentially decreasing expression during subsequent stages of embryonic development. The early embryonic onset and tissue specificity of FMR-1 gene expression is consistent with involvement in the fragile X phenotype, and also suggests additional organ systems in which clinical manifestations of reduced FMR-1 gene expression may occur.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1061-4036
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:geneSymbol |
FMR-1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
36-43
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8490651-Adult,
pubmed-meshheading:8490651-Animals,
pubmed-meshheading:8490651-Base Sequence,
pubmed-meshheading:8490651-Blotting, Northern,
pubmed-meshheading:8490651-Brain,
pubmed-meshheading:8490651-DNA, Single-Stranded,
pubmed-meshheading:8490651-Fetus,
pubmed-meshheading:8490651-Fragile X Mental Retardation Protein,
pubmed-meshheading:8490651-Fragile X Syndrome,
pubmed-meshheading:8490651-Gene Expression,
pubmed-meshheading:8490651-Humans,
pubmed-meshheading:8490651-In Situ Hybridization,
pubmed-meshheading:8490651-Male,
pubmed-meshheading:8490651-Mice,
pubmed-meshheading:8490651-Molecular Sequence Data,
pubmed-meshheading:8490651-Nerve Tissue Proteins,
pubmed-meshheading:8490651-Organ Specificity,
pubmed-meshheading:8490651-RNA-Binding Proteins,
pubmed-meshheading:8490651-Testis
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pubmed:year |
1993
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pubmed:articleTitle |
Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome.
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pubmed:affiliation |
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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