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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1993-6-17
|
| pubmed:abstractText |
Forty-four preterm infants of less than 30 weeks gestation and birthweight < or = 1250 g, with severe bronchopulmonary dysplasia requiring mechanical ventilation for at least 28 days, were reviewed. Twenty-seven infants (61%) survived; 17 died. There were no significant differences between survivors and non-survivors with respect to birthweight, gestational age, sex, Apgar score at 5 min or pulmonary diagnosis. Non-survivors displayed more severe changes on chest X-ray than the survivors. Peak inspiratory pressure (PIP), ventilator rate (VR), ventilator index and mean airways pressure were significantly higher in the non-surviving infants on days 2, 3, 4, 7, 14, 21 and 28, with non-survivors also having significantly higher alveolar-arterial oxygen gradients and lower arterial-alveolar oxygen ratios than the survivors. Discriminant analysis with cross-validation by pairing PIP and VR on day 28 produced a positive predictive value for non-survival of 88% and a negative predictive value of 89%. This result was better than was obtained for any other pair of ventilator parameter or oxygenation index. Discriminant analysis by combining X-ray appearances with ventilator settings did not improve the prediction. Having established a statistical model based on the PIP and VR of ventilator-dependent preterm infants on day 28, the outcome can be predicted with a high degree of confidence. This has the immediate potential application of indicating to staff in the neonatal unit a realistic approach to take when counselling parents of these infants.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1034-4810
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
107-12
|
| pubmed:dateRevised |
2007-9-24
|
| pubmed:meshHeading |
pubmed-meshheading:8489789-Bronchopulmonary Dysplasia,
pubmed-meshheading:8489789-Female,
pubmed-meshheading:8489789-Humans,
pubmed-meshheading:8489789-Infant, Newborn,
pubmed-meshheading:8489789-Male,
pubmed-meshheading:8489789-Prognosis,
pubmed-meshheading:8489789-Reproducibility of Results,
pubmed-meshheading:8489789-Respiration, Artificial,
pubmed-meshheading:8489789-Respiratory Function Tests,
pubmed-meshheading:8489789-Retrospective Studies,
pubmed-meshheading:8489789-Sensitivity and Specificity,
pubmed-meshheading:8489789-Severity of Illness Index,
pubmed-meshheading:8489789-Survival Rate,
pubmed-meshheading:8489789-Treatment Outcome
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Prediction of outcome of preterm infants with severe bronchopulmonary dysplasia.
|
| pubmed:affiliation |
Department of Neonatology, Mater Mothers' Hospital, South Brisbane, Queensland, Australia.
|
| pubmed:publicationType |
Journal Article
|