Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1993-6-15
|
| pubmed:abstractText |
Using a mouse prostate reconstitution (MPR) model system, strain-specific responses to the ras and myc oncogenes were investigated. When ras + myc were introduced into both the mesenchymal and epithelial compartments of the urogenital sinus, poorly differentiated prostate cancer was produced at a high frequency (> 90%) in inbred C57BL/6 mice. In contrast, under similar conditions, inbred BALB/c MPRs formed benign prostatic hyperplasia that converted to cancer at a low frequency (< 10%). Restricting the oncogenes to the mesenchymal or epithelial compartments revealed that oncogene activities were more pronounced in the mesenchyme of C57BL/6 mice and resulted in elevated transforming growth factor-beta 1 expression along with a severe desmoplastic reaction. Heterologous MPRs composed of BALB/c mesenchyme and C57BL/6 epithelium or vice versa demonstrated that intrinsic properties of BALB/c mesenchyme can arrest the progression of ras + myc-initiated C57BL/6 epithelium from benign hyperplasia to malignant carcinoma.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0899-1987
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:geneSymbol |
Ha-ras,
myc
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
165-79
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8489712-Animals,
pubmed-meshheading:8489712-Base Sequence,
pubmed-meshheading:8489712-Cell Communication,
pubmed-meshheading:8489712-Cell Differentiation,
pubmed-meshheading:8489712-Epithelium,
pubmed-meshheading:8489712-Female,
pubmed-meshheading:8489712-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8489712-Genes, myc,
pubmed-meshheading:8489712-Genes, ras,
pubmed-meshheading:8489712-Male,
pubmed-meshheading:8489712-Mesoderm,
pubmed-meshheading:8489712-Mice,
pubmed-meshheading:8489712-Mice, Inbred BALB C,
pubmed-meshheading:8489712-Mice, Inbred C57BL,
pubmed-meshheading:8489712-Molecular Sequence Data,
pubmed-meshheading:8489712-Oligodeoxyribonucleotides,
pubmed-meshheading:8489712-Polymerase Chain Reaction,
pubmed-meshheading:8489712-Prostatic Neoplasms,
pubmed-meshheading:8489712-RNA, Messenger,
pubmed-meshheading:8489712-Time Factors
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Genetic predisposition and mesenchymal-epithelial interactions in ras+myc-induced carcinogenesis in reconstituted mouse prostate.
|
| pubmed:affiliation |
Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|