|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1993-6-8
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|
pubmed:abstractText |
Human circulating lymphocytes were isolated and incubated with ethanol. Cytosolic, membrane-bound and total detergent extractable protein kinase C (PKC) activities were measured. Exposure to ethanol (100 mm) resulted in an increase in PKC activity, with membrane-associated PKC activity increasing with respect to cytosolic activity at 5 min of exposure. Higher concentrations of ethanol up to 200 mm were associated with increases in total detergent extractable PKC activity. Ethanol was the most potent of a series of straight chain alcohols studied for their effects on detergent-extractable PKC activity.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0145-6008
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
351-4
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8488978-1-Butanol,
pubmed-meshheading:8488978-1-Propanol,
pubmed-meshheading:8488978-Butanols,
pubmed-meshheading:8488978-Cells, Cultured,
pubmed-meshheading:8488978-Dose-Response Relationship, Drug,
pubmed-meshheading:8488978-Ethanol,
pubmed-meshheading:8488978-Humans,
pubmed-meshheading:8488978-Lymphocytes,
pubmed-meshheading:8488978-Methanol,
pubmed-meshheading:8488978-Protein Kinase C
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Ethanol exposure increases total protein kinase C activity in human lymphocytes.
|
|
pubmed:affiliation |
Division of Clinical Pharmacology, Brown University School of Medicine, Providence, Rhode Island.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
