Linked Life Data

848875

Source:http://linkedlifedata.com/resource/pubmed/id/848875

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1977-5-25
pubmed:abstractText
Some of the mechanisms of tolerance to the foetal allograft have been studied in vivo, both at cellular and humoral level. It has been shown that immunoglobulins, mostly IgG1, can be detected and eluted from the placenta of allogeneic and syngeneic pregnancies in a wide variety of combination (CBA, C57Ks A/Jax, Balb C, DBA2). These immunoglobulins, in the case of allogeneic pregnancy, bind to paternal thymocytes exclusively, demonstrating antibody activity toward paternal antigens. They promote (although partly "non-specifically") direct allogeneic mast cell degranulation. In vivo, eluates only from a C57Ks female X A/Jax male placenta exclusively induce a significant enhancement of SA1 (A/Jax, h-2a strain) tumor graft in C57Ks (H-2d) recipients. Intraperitoneal transfer of 1.0 to 1.7 X 10(7) spleen cells from C57Ks two weeks pregnant from A/Jax male does also promotes SA1 growth and survival. T and B enriched population, obtained by the nylon wool techniques, display similar activity. Further experiments are in progress to discard T cell contamination in the B enriched population and to study eventual macrophage involvement. Thus, two agents of the facilitation reaction--suppressor cells and enhancing antibodies--have been demonstrated in vivo during pregnacy, protecting the foetus against hazards of the rejection reaction, which is also demonstrates by other in vivo techniques in our laboratory.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0300-4910
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Enhancing antibodies and supressive cells in maternal anti-fetal immune reaction].
pubmed:publicationType
Journal Article, English Abstract