Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1993-6-4
|
pubmed:abstractText |
The structural gene locus for apolipoprotein E (apo E) is polymorphic. The relative apo E allele frequencies and the influence of this polymorphism on serum lipoprotein concentrations were studied in 8- to 17-year-old black (n = 444) and white (n = 446) children from the community of Bogalusa, LA. The frequencies of the e2, e3, and e4 alleles for white males/females were 0.027/0.024, 0.849/0.823, and 0.124/0.153, respectively; corresponding values for black males/females were 0.087/0.074, 0.713/0.721, and 0.20/0.205, respectively. Apo E phenotype distributions and allele frequencies showed a significant race difference, but no sex difference. Significant differences among apo E phenotypes were noted for total cholesterol, low-density lipoprotein cholesterol (LDL-C), and apo B in both races; significant effects were noted for high-density lipoprotein cholesterol (HDL-C) and apo A-I in black children, but not in white children. Among white children, the average excess of the apo e2 allele showed lower LDL-C (-12.5 mg/dL) and apo B (-15.8 mg/dL) concentrations, while the average excess of the apo e4 allele showed higher LDL-C (7.0 mg/dL) and apo B (7.5 mg/dL) concentrations. Black children showed a similar trend for these variables, but to a lesser degree; in addition, the average excess of apo e2 allele showed higher HDL-C (12.8 mg/dL) and apo A-I (8.3 mg/dL) concentrations in this racial group. It is noteworthy that the association of apo E polymorphism with serum lipoprotein concentrations noted in adults can be seen already in children.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0026-0495
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
42
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
381-6
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:8487659-Adolescent,
pubmed-meshheading:8487659-African Continental Ancestry Group,
pubmed-meshheading:8487659-Alleles,
pubmed-meshheading:8487659-Apolipoproteins E,
pubmed-meshheading:8487659-Child,
pubmed-meshheading:8487659-European Continental Ancestry Group,
pubmed-meshheading:8487659-Female,
pubmed-meshheading:8487659-Genes,
pubmed-meshheading:8487659-Humans,
pubmed-meshheading:8487659-Lipoproteins,
pubmed-meshheading:8487659-Louisiana,
pubmed-meshheading:8487659-Male,
pubmed-meshheading:8487659-Phenotype,
pubmed-meshheading:8487659-Polymorphism, Genetic
|
pubmed:year |
1993
|
pubmed:articleTitle |
Apolipoprotein E polymorphism and its association with serum lipoprotein concentrations in black versus white children: the Bogalusa Heart Study.
|
pubmed:affiliation |
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|