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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-6-10
|
| pubmed:abstractText |
The effect of dopamine on the arterioles (50.8-95.2 microns) in the cremaster muscle was examined to determine its effect on microcirculation. Anesthetized rats were used under a light microscope connected to a videocamera. Drugs were applied using small round filter paper (370 microns in diameter) containing the drug and placed in the immediate vicinity of the arteriole on the cremaster with a micromanipulator. The dose of the drug applied was represented by concentration of the drug solution in which the filter paper was immersed. Dopamine (10(-6)-10(-4)M) induced neither constriction nor dilation of the arteriole in the cremaster. Papaverine (10(-2)M) did not dilate the arteriole. However, the arterioles were constricted by noradrenaline (10(-6)-10(-4)M) and vasopressin (10(-7)M) in a dose-dependent manner. Noradrenaline (10(-4)M)-induced constriction was blocked by concomitant application of dopamine (10(-4)M). This effect of dopamine was antagonized by SCH23390 (10(-3)M). However, isoproterenol (10(-3)M) did not affect the arteriole, nor inhibit noradrenaline (10(-4)M)-induced constriction of the arterioles. While forskolin (10(-2)M) alone did not produce constriction or dilation of the arterioles, it inhibited noradrenaline (10(-4)M)-induced constriction of the arteriole. These results suggest that dopamine prevents the constriction of the arteriole induced by noradrenaline, by activation of DA1 receptors, which activates adenylate cyclase.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
0018-2052
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1-7
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| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading |
pubmed-meshheading:8486519-Abdominal Muscles,
pubmed-meshheading:8486519-Animals,
pubmed-meshheading:8486519-Arterioles,
pubmed-meshheading:8486519-Dopamine,
pubmed-meshheading:8486519-Forskolin,
pubmed-meshheading:8486519-Isoproterenol,
pubmed-meshheading:8486519-Male,
pubmed-meshheading:8486519-Norepinephrine,
pubmed-meshheading:8486519-Rats,
pubmed-meshheading:8486519-Rats, Wistar,
pubmed-meshheading:8486519-Vasoconstriction,
pubmed-meshheading:8486519-Vasopressins
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Inhibitory effects of dopamine on noradrenaline-induced constriction of arterioles in vivo in the striated cremaster muscle.
|
| pubmed:affiliation |
Department of Pharmacology, Hiroshima University School of Medicine, Japan.
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| pubmed:publicationType |
Journal Article
|