Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-6-8
pubmed:abstractText
Murine MoAb 1-22-3 has already been reported to bind to the mesangial cell surface and to cause transient proteinuria and mesangial morphological changes characterized by mesangiolysis, subsequent mesangial cell proliferation and mesangial matrix increase by a single i.v. injection. In this study, MoAb-induced glomerulopathy was quantitatively analysed. No correlation between the severity of mesangial morphological changes and the degree of proteinuria was detected (r = 0.190). The minimum dose injected to induce abnormal proteinuria was 25 micrograms. This dose corresponded to 1.79 micrograms/2 kidneys 30 min after MoAb injection. The highest average level of proteinuria was observed in rats injected with 500 micrograms of MoAb, and less proteinuria was observed in rats injected with 10.0, 5.0 and 2.0 mg. Although the amounts of kidney-fixing MoAb and the subsequent deposition of rat C3 in the high-dose-injected group were larger than in the 500 micrograms injected group, the numbers of infiltrating inflammatory cells were the same in both groups. No correlations between the degrees of such mediators and proteinuria were observed.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-1376651, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-142595, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-14278226, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-1569407, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-1735184, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-2374609, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-2874509, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-2892961, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-3367561, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-3397534, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-3495569, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-3517487, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-3535371, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-3537521, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-3889676, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-4160044, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-4956917, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-589877, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-6239058, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-6348567, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-6460074, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-6499450, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-6616977, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-7021031, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-7076216, http://linkedlifedata.com/resource/pubmed/commentcorrection/8485919-7400310
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
342-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Quantitative study of mesangial injury with proteinuria induced by monoclonal antibody 1-22-3.
pubmed:affiliation
Department of Immunology, Niigata University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't